Routes from largest cities in North America to Isabela, Puerto Rico
- Mexico City, Mexico Isabela
- New York City, United States Isabela
- Los Angeles, United States Isabela
- Chicago, United States Isabela
- Toronto, Canada Isabela
- Brooklyn, United States Isabela
- Borough of Queens, United States Isabela
- Santo Domingo, Dominican Republic Isabela
- Havana, Cuba Isabela
- Houston, United States Isabela
- Iztapalapa, Mexico Isabela
- Ecatepec, Mexico Isabela
- Guadalajara, Mexico Isabela
- Montréal, Canada Isabela
- Puebla, Mexico Isabela
- Philadelphia, United States Isabela
- Ciudad Juárez, Mexico Isabela
- Manhattan, United States Isabela
- Phoenix, United States Isabela
- The Bronx, United States Isabela
- Tijuana, Mexico Isabela
- San Antonio, United States Isabela
- San Diego, United States Isabela
- Port-au-Prince, Haiti Isabela
- Ciudad Nezahualcoyotl, Mexico Isabela
- Santiago de los Caballeros, Dominican Republic Isabela
- Dallas, United States Isabela
- Gustavo A. Madero, Mexico Isabela
- Gustavo A. Madero, Mexico Isabela
- Monterrey, Mexico Isabela
- León, Mexico Isabela
- Calgary, Canada Isabela
- Guatemala City, Guatemala Isabela
- Zapopan, Mexico Isabela
- Managua, Nicaragua Isabela
- San Jose, United States Isabela
- Kingston, Jamaica Isabela
- Tegucigalpa, Honduras Isabela
- Naucalpan de Juárez, Mexico Isabela
- Indianapolis, United States Isabela
- Jacksonville, United States Isabela
- Ottawa, Canada Isabela
- Chihuahua, Mexico Isabela
- San Francisco, United States Isabela
- Austin, United States Isabela
- Columbus, United States Isabela
- Fort Worth, United States Isabela
- Charlotte, United States Isabela
- Álvaro Obregón, Mexico Isabela
- Guadalupe, Mexico Isabela
- Mérida, Mexico Isabela
- Tlalnepantla, Mexico Isabela
- Detroit, United States Isabela
- Edmonton, Canada Isabela
- Santo Domingo Oeste, Dominican Republic Isabela
- San Luis Potosí, Mexico Isabela
- Culiacán, Mexico Isabela
- Mississauga, Canada Isabela
- Aguascalientes, Mexico Isabela
- Acapulco de Juárez, Mexico Isabela
- El Paso, United States Isabela
- Memphis, United States Isabela
- New South Memphis, United States Isabela
- North York, Canada Isabela
- Winnipeg, Canada Isabela
- Coyoacán, Mexico Isabela
- Santiago de Querétaro, Mexico Isabela
- Saltillo, Mexico Isabela
- Baltimore, United States Isabela
- Boston, United States Isabela
- Seattle, United States Isabela
- Tlalpan, Mexico Isabela
- Washington, D.C., United States Isabela
- Denver, United States Isabela
- Vancouver, Canada Isabela
- Scarborough, Canada Isabela
- Mexicali, Mexico Isabela
- Hermosillo, Mexico Isabela
- Milwaukee, United States Isabela
- Morelia, Mexico Isabela
- New Kingston, Jamaica Isabela
- Portland, United States Isabela
- Las Vegas, United States Isabela
- Oklahoma City, United States Isabela
- South Boston, United States Isabela
- Veracruz, Mexico Isabela
- Santiago de Cuba, Cuba Isabela
- Albuquerque, United States Isabela
- Cancún, Mexico Isabela
- Nashville, United States Isabela
- Québec, Canada Isabela
- San Salvador, El Salvador Isabela
- Santa María Chimalhuacán, Mexico Isabela
- Torreon, Mexico Isabela
- Cuauhtémoc, Mexico Isabela
- Ciudad López Mateos, Mexico Isabela
- Tucson, United States Isabela
- Hamilton, Canada Isabela
- Toluca, Mexico Isabela
- Reynosa, Mexico Isabela
- Fresno, United States Isabela
- Tlaquepaque, Mexico Isabela
- San Pedro Sula, Honduras Isabela
- Tuxtla Gutiérrez, Mexico Isabela
- Cuautitlán Izcalli, Mexico Isabela
- Mixco, Guatemala Isabela
- Staten Island, United States Isabela
- Sacramento, United States Isabela
- Long Beach, United States Isabela
- Kansas City, United States Isabela
- Victoria de Durango, Mexico Isabela
- Heroica Matamoros, Mexico Isabela
- Venustiano Carranza, Mexico Isabela
- San Nicolás de los Garza, Mexico Isabela
- Carrefour, Haiti Isabela